Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure

R Ramchandra; SG Hood; R Frithiof; CN May

Journal article

Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure

R Ramchandra, SG Hood, R Frithiof, CN May

American Journal of Physiology Regulatory Integrative and Comparative Physiology | Published : 2009

DOI: 10.1152/ajpregu.00191.2009

Abstract

Sympathetic nerve activity (SNA) consists of discharges that vary in amplitude and frequency, reflecting the level of recruitment of nerve fibers and the rhythmic generation and entrainment of activity by the central nervous system. It is unknown whether selective changes in these amplitude and frequency components account for organ-specific changes in SNA in response to alterations in blood volume or for the impaired SNA responses to volume changes in heart failure (HF). To address these questions, we measured cardiac SNA (CSNA) and renal SNA (RSNA) simultaneously in conscious, normal sheep and sheep in HF induced by rapid ventricular pacing. Volume expansion decreased CSNA (-62 ± 10%, P < ..

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University of Melbourne Researchers

Clive May Author

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Awarded by National Heart, Lung, and Blood Institute

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) Grants 232313 and 509204 and National Heart, Lung, and Blood Institute Grant 5-R01-HL-074932. R. Ramchandra is the recipient of National Heart Foundation Postdoctoral Fellowship PF 07M 3293 and C. N. May was supported by NHMRC Research Fellowships 350328 and 566819. R. Frithiof is the recipient of a Postdoctoral Fellowship from the Swedish Heart-Lung Foundation.